Abstract Library

#585 Global microRNA profiling of small intestine neuroendocrine tumors (SI-NETs) and establishment of a method to study serum microRNA expression from the same tumors

Introduction: MicroRNAs (miRNAs) are important post-transcriptional regulatorsin biological processes and function either as tumor suppressors or oncogenes.

Conference:

Presenting Author:

Authors: Li S, Martijn C, Essaghir A, Lloyd R, Demoulin J,

Keywords: small-intestine neuroendocrine-tumors, microRNA profiling, serum-miRNA expression,

#424 Role of MicroRNAs in Small Intestine Neuroendocrine Tumors

Introduction: Small intestinal neuroendocrine tumors (SI-NETs) arise from enterochromaffin cells, which belong to the endocrine system. MicroRNAs (miRs) are post-transcriptional regulators. They control multiple biological processes often functioning either as tumor suppressor genes or oncogenes.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Li S, Martijn C, Essaghir A, Lloyd R, Demoulin J,

Keywords: small intestine, neuroendocrine tumors, microRNA profiling ,

#422 The Somatostatin Analogue Octreotide Inhibits Growth of Neuroendocrine Tumor Cells by Triggering Janus Faced Proteins

Introduction: Octreotide is a somatostatin analogue, which improves the management of neuroendocrine tumor (NET) patients. Octreotide acts through somatostatin receptors (SSTRs). However, the molecular mechanisms leading to successful therapy or curative effects are largely unknown, particularly when SSTRs levels are low or absent.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Li S, Martijn C, Cui T, Essaghir A, Luque R,

Keywords: CNDT2.5, Octreotide, neuroendocrine cell growth/differentiation,

#355 MicroRNA Signatures as Novel Biomarkers in Small Intestine Neuroendocrine Tumors

Introduction: Small intestine (SI) neuroendocrine tumors (NET) arise from serotonin-producing intraepithelial cells in the SI referred to as enterochromafin cells. The detection of SI-NETs is often concomitant with the appearance of hepatic metastasis thus most patients with SI-NET have metastases at initial presentation. MicroRNAs (miRs) are post-transcriptional key regulators in tumorigenesis which regulate expression of other genes. Little evidence of miR expression or deregulation in SI-NETs has been reported.

Conference:

Presenting Author:

Authors: Li S, Ahmed E, Martijn C, Lloyd R, Demoulin J,

Keywords: Small intestine neuroendocrine tumors, laser microdissection, microRNA array, micro RNA targets. ,

#200 Genome-Wide MicroRNA Expression in Small Intestine Neuroendocrine Tumors (“Midgut carcinoids”): Upregulation of miRNA-182, miRNA-183 and Downregulation of miRNA-215

Introduction: MicroRNAs (miRs) may regulate cell proliferation, differentiation, apoptosis and function as tumor suppressors or oncogenes. MiR expression is not characterized in neuroendocrine midgut carcinoids.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Li S, Essaghir A, Martijn C, Lloyd R, Demoulin J,

Keywords: midgut specimens, microdissected normal enterochromaffin cells, Affymetrix, microRNA expression,